Síntesis de nanopartículas capaces de encapsular material bioactivo mediante la elaboración de un sistema de atomización electrohidrodinámica para aplicaciones en vacunas nasales.

Controlled drug release systems are innovative techniques that offer advantages over conventional methods, enabling the localization of bioactive payloads in specific regions and the control of drug concentrations within therapeutic ranges for extended periods. Administration systems are utilized at microscopic or nanometric scales, depending on their application and area of ​​interest. These systems involve encapsulating a bioactive compound (core) within a biopolymer matrix (shell) to facilitate the diffusion of the bioactive payload. The electrospraying technique is employed to produce simple or encapsulated nanoparticles, using a high electric field to electrostatically deposit the generated particles onto a collecting plate for recovery.

Commercially available systems with high electric potential are present worldwide; however, their high costs limit the acquisition and implementation of this technology. The Technological Institute of Costa Rica has the capacity to design and construct a system using previously obtained, easily accessible, and manipulable equipment. This aims to be used to produce bioactive material-incorporated biopolymer nanoparticles, as well as for other future investigations requiring nanoparticle generation. In this research proposal, an electrohydrodynamic atomization device will be manufactured, enabling the development of nanoparticulate systems based on biocompatible biopolymers, capable of encapsulating bioactive material for controlled release through nasal vaccines. This could contribute to an improved biological response and, consequently, higher treatment effectiveness

Sintetizar nanopartículas capaces de encapsular material bioactivo mediante la elaboración de un sistema de atomización electrohidrodinámica local para aplicaciones de vacunas nasales.

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