INNOrganic: INNovation in ORGANIC study models for preclinical testing Fase I (GI)*: Prueba de concepto en la modelación de un sistema digestivo in vitro en un sistema organ-on-a-chip * GI: Gastrointestinal

Traditional research that aims to recreate or develop strategies to modify human biology tends to focus
on a target organ or tissue, thus omitting the systemic effect and sequential transformation that can
occur in molecules when interacting with different organs. Organ-on-a-chip technology refers to a
physiological biomimetic system that simulates the cellular microenvironment in terms of tissue
interfaces and mechanical stimulation, generating more reliable results than 2D cultures and animal
models, which also presents ethical advantages by dispensing with or minimizing the use of laboratory
animals. This technology is available in very few places in the world, and allows accelerating the
characterization and development of substances with potential benefits for human health, at a
nutritional and biomedical level, contributing to the institutional knowledge axis (goal) "Health". This is
important because it also contributes to the implementation of technologies and services that will
empower teaching, training, research-outsourcing services, and other activities carried out by the
institution in its various modalities, as well as strengthening the research and development departments
of biomedical industries (equipment, devices and pharmacological) established in Costa Rica.

Establecer un modelo in vitro simulador del sistema digestivo humano como una
herramienta de evaluación del comportamiento de sustancias consumidas por
vía oral

Escuela de Biología: Biotecnología Médica
Escuela de Ingeniería en Electrónica: Dispositivos Electrónicos