Evaluación del mecanismo de entrega de vitamina B12 nanoencapsulada con biopolimeros en modelos intestinales in vitro

The development of intelligent systems for the administration of substances with difficult absorption or low bioavailability in the body is a key area of ​​interest in medical research and development. Vitamin B12 (VB12) is a case in point, as there are significant barriers at the intestinal level that can prevent its absorption. Encapsulation in biopolymers offers a promising approach to improve its natural properties. VB12 deficiency is a public health problem that affects millions of people and causes serious anemic and neurological consequences. This problem is not limited only to populations that have direct physiological considerations for its assimilation, but also to those that due to treatments or external conditions may compromise the bioavailability of this compound in the body. These challenges are particularly pronounced in vulnerable populations where access to treatment is limited and administration methods are restricted, often requiring large dosing volumes. This work proposes the encapsulation of VB12 in biopolymers such as alginate, chitosan and zein, all of which are of biological origin and can be tailored by green chemistry to improve the gastrointestinal absorption of this cobalamin. The encapsulates will be characterized by physicochemical analysis. Additionally, the pharmacokinetics and pharmacodynamics of the nanoencapsulates will be studied in vitro using advanced technologies such as microfluidic organ-on-chip systems. This research proposes innovative solutions by applying knowledge from the fields of nano and medical biotechnology, offering an effective strategy to address nutritional deficiencies in vulnerable populations with the aim of improving the bioavailability of VB12. Furthermore, the results of this study are expected to open new avenues for the research and development of personalized nutritional therapies.

Desarrollar un mecanismo inteligente para la entrega a nivel intestinal de vitamina B12 mediante la encapsulación bio-polimérica

Aplicaciones Biomédicas