Espectro de propiedades de implantes multifuncionales mediante herramientas computacionales, fabricación avanzada y funcionalización multifásica para aplicaciones en tejido óseo

This research proposal integrates computational design, additive manufacturing, and surface engineering to develop patient-specific bone implants with high biological and mechanical performance. It combines two thrusts: (i) the development of bioactive, immunomodulatory multiphase coatings, and (ii) the creation of parametric computational protocols for the design and structural validation of orthopedic implants. The project is grounded in the premise that a device’s clinical efficacy depends both on its internal architecture and on the physicochemical and biological properties of its surface. Accordingly, we propose an integrated system in which computational models—medical imaging, 3D segmentation, CAD, and finite element analysis (FEA)—define optimized macro-geometries and porous microarchitectures, while the multiphase coatings—based on inorganic phases (hydroxyapatite, β-tricalcium phosphate [β-TCP], magnesium phosphates) and organic phases (PCL, PVA, chitosan)—serve as bioactive interfaces that promote osseointegration and modulate the immune response. Traceable and reproducible protocols will be developed for implant modeling, fabrication, and validation. Coatings will be deposited using advanced techniques and characterized by electron microscopy, FTIR spectroscopy, and mechanical testing in accordance with ASTM standards. Biological validation with preclinical in-vitro testing is planned to evaluate characteristics such as biocompatibility and the absence of bioincompatible ions, compounds, or other residues. The result will be a comprehensive, collaborative system for co-design and functionalization, with potential for transfer to human and veterinary applications, strengthening the advanced biomaterials line of the Bio-Inspired Materials and Processes (MPBI) group.

Desarrollar proceso de optimización de implantes óseos que combine el diseño computacional parametrizado, la manufactura aditiva y la ingeniería de recubrimientos multifásicos bioactivos.

1. Mecánica de Materiales

2. Caracterización de Materiales y Ensayos No-Destructivos

3. Tecnologías avanzadas para el desarrollo y aplicación de materiales.