Project Details
Description
The design of bioabsorbable implants has been developed as an innovative solution in medicine that seeks to address the need for follow-up surgeries for the replacement or removal of implanted
components and improve the quality of life of patients. This project focuses on the research and development of orthopedic implant prototypes made from magnesium-c nanostructured through high-pressure torsion (HPT), as well as the addition of alloying elements such as zinc (Zn) and strontium (Sr) to enhance their mechanical properties, biocompatibility, and
electrochemical response. The methodology incorporates the fabrication of Mg-Ca alloys and other elements Zn and Sr, with different concentrations integrated into the matrix through HPT
processing. Furthermore, the alloys are characterized before and after processing using scanning electron microscopy (SEM), complemented by energy-dispersive X-ray spectroscopy (EDS) and
differential scanning calorimetry (DSC). Additionally, rystallographic characterization is performed using transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR) for the study of corrosion products. Moreover, the mechanical properties are evaluated through Vickers microhardness measurements, tensile and fatigue tests.
A computational model of the implant prototype will also be designed using the CAD software SolidWorks, and simulations will be conducted to replicate mechanical and electrochemical
behaviors. Once the prototype is designed, the nanostructured material will be machined using Wire Electrical Discharge Machining (EDM), and in vitro studies of the prototype will be carried out to evaluate the biocompatibility and corrosion behavior of the implants; if feasible, in vivo studies will be conducted to assess the same behaviors. The activities will take place at Centro de Investigación y Extensión en Materiales (CIEMTEC), Laboratorio de Microscopia, Escuela de Química located at Campus Central del Instituto Tecnológico de Costa Rica. Finally, the goal is to manufacture an implant that meets the necessary mechanical requirements for orthopedic applications and has a controlled degradation rate to promote bone regeneration without negative impacts on patients.
components and improve the quality of life of patients. This project focuses on the research and development of orthopedic implant prototypes made from magnesium-c nanostructured through high-pressure torsion (HPT), as well as the addition of alloying elements such as zinc (Zn) and strontium (Sr) to enhance their mechanical properties, biocompatibility, and
electrochemical response. The methodology incorporates the fabrication of Mg-Ca alloys and other elements Zn and Sr, with different concentrations integrated into the matrix through HPT
processing. Furthermore, the alloys are characterized before and after processing using scanning electron microscopy (SEM), complemented by energy-dispersive X-ray spectroscopy (EDS) and
differential scanning calorimetry (DSC). Additionally, rystallographic characterization is performed using transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR) for the study of corrosion products. Moreover, the mechanical properties are evaluated through Vickers microhardness measurements, tensile and fatigue tests.
A computational model of the implant prototype will also be designed using the CAD software SolidWorks, and simulations will be conducted to replicate mechanical and electrochemical
behaviors. Once the prototype is designed, the nanostructured material will be machined using Wire Electrical Discharge Machining (EDM), and in vitro studies of the prototype will be carried out to evaluate the biocompatibility and corrosion behavior of the implants; if feasible, in vivo studies will be conducted to assess the same behaviors. The activities will take place at Centro de Investigación y Extensión en Materiales (CIEMTEC), Laboratorio de Microscopia, Escuela de Química located at Campus Central del Instituto Tecnológico de Costa Rica. Finally, the goal is to manufacture an implant that meets the necessary mechanical requirements for orthopedic applications and has a controlled degradation rate to promote bone regeneration without negative impacts on patients.
General Objective
Fabricar y caracterizar las aleaciones Mg-x%Ca, Mg-x%Ca Zn y Mg-x%Ca-x%Sr nanoestructuradas por HPT para desarrollar un prototipo de implante bioabsorbible con una tasa de corrosión controlada, propiedades mecánicas similares al hueso y biocompatibilidad.
Research Lines
1. Tecnologías avanzadas para el desarrollo y aplicación de materiales.
2. Caracterización de Materiales y Ensayos no-destructivos.
3. Degradación y Protección de Materiales.
2. Caracterización de Materiales y Ensayos no-destructivos.
3. Degradación y Protección de Materiales.
| Short title | DMed |
|---|---|
| Status | Active |
| Effective start/end date | 1/01/25 → 31/12/26 |
Keywords
- magnesium-calcium alloys
- severe plastic deformation
- high-pressure torsion
- degradation rate
- bioabsorbable implants
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