BioFab 3D: Desarrollo de Modelos Anatómicos Personalizados para Evaluación Preclínica mediante Manufactura Aditiva

The project "BioFab 3D: Innovation in Personalized Anatomical Models for Preclinical Evaluation through Additive Manufacturing" aims to develop personalized anatomical models that precisely replicate the physical, haptic, and mechanical properties of human tissues, intended for preclinical studies of medical devices. This project will address the current limitations of cadaveric and artificial models, which do not adequately replicate the mechanical properties or the integration between different anatomical structures.

The project focuses on integrating advanced additive manufacturing technologies, such as stereolithography (SLA) and bioprinting, along with design techniques like Design for Additive Manufacturing (DfAM), implicit design, and field-driven design (FDD). These tools will enable the creation of anatomical models that not only replicate the geometry of human tissues but also reproduce their mechanical and haptic properties under dynamic loading conditions through the precise reconstruction of anatomical structures from medical images

The project will involve international collaboration with the Future Manufacturing Technology Research Group at the University of Oulu, Finland, which will participate in fabricating some samples and the fatigue characterization of the developed models. Additionally, there will be collaboration with the School of Veterinary Medicine at the National University of Costa Rica in developing and fabricating materials and structures through bioprinting. This collaboration will enable the creation of models that incorporate 3D-printed biological tissues, increasing the accuracy and relevance of anatomical models for preclinical applications.

The remaining design, model fabrication, and mechanical characterization activities will be carried out jointly between the School of Industrial Design Engineering and the School of Materials Science and Engineering at the Costa Rica Institute of Technology through the Bio-Inspired Materials and Processes Research Group. This team will be responsible for optimizing designs and validating them through mechanical testing to ensure the functionality and precision of the developed models.

Ultimately, this project will set a new standard in the creation of anatomical models for preclinical evaluation, significantly impacting the development of safer and more effective medical devices

Through international and local collaborations, the project will incorporate best practices and technologies, advancing the integration of additive manufacturing in modern medicine

Desarrollar modelos anatómicos personalizados utilizando manufactura aditiva, que repliquen con precisión las propiedades físicas, hapticas y mecánicas de tejidos humanos, destinados a estudios preclínicos de dispositivos médicos.

1. Diseño contexto y entorno